Raman Optical Activity (ROA) spectrometer

BioTools is the first and only company in the world offering a dedicated commercial spectrometer for the measurement of Raman Optical Activity (ROA). In the second generation of this award-winning product, we have modified the design and added a microscope. The result is an unprecedented technology incorporating:

  • more compact, two-level blueprint to save laboratory space
  • large sample compartment
  • affordable 2-watt laser
  • microscope as an option
  • artifact and birefringence suppression

The ChiralRAMAN is proven by customers to have the highest signal-to-noise RAMAN spectra.

View the ChiralRAMAN-2X brochure

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Raman Optical Activity (ROA)
ROA is the differential response of a molecule to LCP vs. RCP radiation during a vibrational transition. It deals with chiral molecules, which means, as it was expressed by Lord Kelvin in 1884: “I call any geometrical figure, or group of points, chiral, and say that it has chirality, if its image in a plane mirror, ideally realized, cannot be brought to coincide with itself.” The measured ROA spectra of chiral molecules contain important information on their molecular geometries, e.g., conformations or structures.

Intensity of ROA
This tool is sensitive to the electric-electric, the electric-magnetic and the electric-quadrapole dipole moments, EDEDPD, EDMDPD and EDEQPD, respectively. In brief, the measured intensity of an ROA spectrum can be expressed by the Circular Intensity Difference CID:

δ = (IR-IL)/(IR+IL)


δ(180º)=32β(G´)2 / c[45α2+7β(α2)]

Skeletal chirality Conformation

  • Secondary structure
  • Loops
  • turns