Application Notes on Absolute Configuration

Determination of absolute configuration (AC) of chiral molecules is an important step in any field related to chirality but nowhere is it as critical as in the pharmaceutical industry.  The phenomenon of “chiral recognition” − in which the enantiomers of a chiral drug may exhibit differences in biological activity or other processes such as distribution, uptake, and metabolism−makes it a necessity (or requirement) to know the AC not only of the final molecule but as early in the process of development as possible.

READ MORE...

Application Notes on Secondary and High-Order Structure

Formulation of protein-based drugs often requires processes such as lyophilization or spray-drying. However, it has been shown that the freezing and drying steps involved in lyophilization could lead to protein unfolding. This unfolding of the native structure leads to an incomplete recovery of activity and results in aggregation and poor storage stability. These problems are often discerned through tedious and time-consuming measurements of activity or through detailed structure analysis. New and faster analytical techniques are needed in order to accelerate the development of protein formulation.

READ MORE...

Application Notes on Handheld RamTest Identifier

BioTools, Inc. (Jupiter, FL) has recently introduced the RamTest-CSITM handheld Raman identifier well suited for forensic, CSI, homeland security, and other field applications. Unmatched field performance of this easy-to-use, light-weight unit is achieved by utilizing a small-size, state-of-the-art 532 nm excitation source combined with breakthrough engineering design and advanced analytical methodology. As a result, RamTest-CSITM instrument is capable of 5-10x faster analysis / ID of chemicals compared to the other handheld Raman instruments currently available on the market.

READ MORE...

Application Notes on Ram-532-NANO

Due to their unique electronic, physical and mechanical properties, carbon nanotubes (CNTs) are being increasingly used in the fields of electronics and semiconductors, advanced materials, batteries and capacitors, aerospace and defense. The global CNTs / CNT-based product market is projected to reach 5.64 Billion USD by 2020, with annual growth rate (CAGR) of 20.1%.

As commercial CNT production increases, a need to control the quality of produced or purchased CNTs also increases. Raman spectroscopy is one of the most suitable analytical techniques for CNT characterization and/or quality control.

READ MORE...

Application Notes on Explosive Detection

Data from Global Terrorism Database shows that number of terrorist attacks utilizing explosive devices has dramatically increased within last decade. Numerous analytical methods, including portable Raman, have been developed to enable detection of explosives, their precursors and / or breakdown products at the field. In this application note, it is directly demonstrated that RamTest-CSI Handheld Raman Identifier enables fastest-in-class ID of explosive materials (among handhelds), identification and quantitation of individual components in mixtures, as well as ability to analyze compounds previously considered impossible or hard-to-detect using handheld Raman (examples: ammonia, ammonium nitrate, RDX, biologics). Other CSI applications include but not limited to counterfeit testing (medicine, food, beverages or alcohol products), analysis of biological stains, etc.

READ MORE...